| County Number | County | Rate of HIV per 100,000, 1983-2000 | County / State Ratio |
|---|---|---|---|
| 1 | Oconee County | 104.5 | 0.24 |
| 2 | Pickens County | 108.2 | 0.25 |
| 3 | Abbeville County | 170.2 | 0.40 |
| 4 | Cherokee County | 175.7 | 0.41 |
| 5 | Anderson County | 200.3 | 0.47 |
| 6 | Berkeley County | 201.7 | 0.47 |
| 7 | Lancaster County | 218.2 | 0.51 |
| 8 | Chesterfield County | 219.1 | 0.51 |
| 9 | Chester County | 220.5 | 0.51 |
| 10 | Union County | 220.7 | 0.51 |
| 11 | Lexington County | 250.3 | 0.58 |
| 12 | York County | 251.0 | 0.58 |
| 13 | Calhoun County | 274.0 | 0.64 |
| 14 | Newberry County | 279.2 | 0.65 |
| 15 | Laurens County | 280.9 | 0.65 |
| 16 | Beaufort County | 285.9 | 0.66 |
| 17 | Spartanburg County | 286.8 | 0.67 |
| 18 | Saluda County | 288.5 | 0.67 |
| 19 | Dorchester County | 302.5 | 0.70 |
| 20 | Aiken County | 313.1 | 0.73 |
| 21 | Greenwood County | 328.0 | 0.76 |
| 22 | Fairfield County | 341.1 | 0.79 |
| 23 | Greenville County | 354.7 | 0.82 |
| 24 | Kershaw County | 383.4 | 0.89 |
| 25 | Darlington County | 401.6 | 0.93 |
| 26 | Dillon County | 417.3 | 0.97 |
| 27 | Georgetown County | 436.9 | 1.02 |
| 28 | McCormick County | 437.2 | 1.02 |
| 29 | Horry County | 440.8 | 1.02 |
| 30 | Lee County | 452.9 | 1.05 |
| 31 | Colleton County | 501.9 | 1.17 |
| 32 | Hampton County | 502.4 | 1.17 |
| 33 | Barnwell County | 532.5 | 1.24 |
| 34 | Allendale County | 556.3 | 1.29 |
| 35 | Florence County | 571.0 | 1.33 |
| 36 | Clarendon County | 579.3 | 1.35 |
| 37 | Williamsburg County | 597.2 | 1.39 |
| 38 | Marlboro County | 603.6 | 1.40 |
| 39 | Sumter County | 625.4 | 1.45 |
| 40 | Marion County | 641.0 | 1.49 |
| 41 | Jasper County | 667.4 | 1.55 |
| 42 | Charleston County | 673.3 | 1.57 |
| 43 | Orangeburg County | 765.5 | 1.78 |
| 44 | Edgefield County | 815.4 | 1.90 |
| 45 | Bamberg County | 908.6 | 2.11 |
| 46 | Richland County | 987.4 | 2.30 |
| 47 | South Carolina | 430.1 |